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Synthesis, spectroscopic, biological, and theoretical studies of new complexes from ( E )‐3‐(2‐(5, 6‐ diphenyl‐1,2,4‐ triazin‐3‐ yl)hydrazono)butan‐2‐ one oxime
Author(s) -
Samy Fatma,
Shebl Magdy
Publication year - 2020
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.5502
Subject(s) - chemistry , ligand (biochemistry) , octahedral molecular geometry , crystallography , dimethylformamide , metal , electron paramagnetic resonance , metal ions in aqueous solution , octahedron , oxime , stereochemistry , medicinal chemistry , crystal structure , organic chemistry , nuclear magnetic resonance , biochemistry , physics , receptor , solvent
New mononuclear Fe (III), Cu (II), Ag (I), ZrO ( IV) and UO 2 (VI) complexes were synthesized by the reaction of metal ions with ( E )‐3‐(2‐(5, 6‐ diphenyl‐1,2,4‐ triazin‐3‐ yl)hydrazono)butan‐2‐ one oxime. The structures of the metal complexes were characterized using analytical, spectral (infrared, electronic, 1 H NMR, electron spin resonance (ESR), and mass), magnetic moment, molar conductance, thermal gravimetric analysis, and powder X‐ray diffraction (XRD) measurements. All complexes have octahedral geometries except the Cu (II) complex, which has square planar geometry, and the UO 2 (VI) complex, in which the coordination number is seven. The ligand acts as a (neutral, monoanionic or dianionic) tridentate with N 2 O coordinating sites: N ‐azomethine, N ‐triazine, and O ‐oxime. Fluorescence spectral studies were carried out in solid state and in dimethylformamide (DMF). The kinetic parameters of the thermal decomposition stages were calculated using Coats–Redfern equations. The morphological structures of the ligand and some complexes were determined using XRD. The molecular orbital calculations were carried out for the ligand and metal complexes using the Hyperchem 7.52 program on the basis of the PM3 level. The antimicrobial activities of the ligand and its complexes were investigated towards the microorganisms S. aureus and B. subtilis as Gram‐positive bacteria, S. typhimurium and E. coli as Gram‐negative bacteria , C. albicans , and A. fumigatus . The ligand and its complexes showed antitumor activity against Hep G‐2 cell lines, where Cu (II) and Ag (I) complexes seem to be promising as they showed IC 50 values that are lower than and comparable to that of the antitumor drug doxorubicin.