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Synthesis and Fundamental Characterization of Diverse Properties of Biocompatible Cd (II) Phosphor Complex for Cytotoxic Activity and Latent Fingerprint Detection
Author(s) -
Fouad R.
Publication year - 2020
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.5497
Subject(s) - chemistry , phosphor , denticity , ligand (biochemistry) , semicarbazone , luminescence , fluorescence , cytotoxicity , nuclear chemistry , stereochemistry , crystal structure , crystallography , receptor , in vitro , biochemistry , materials science , physics , optoelectronics , quantum mechanics
The development of biocompatible fluorescent materials based on Cd II (d 10 ) systems for cytotoxic application and latent fingerprint detection under UV illumination has not yet been studied that thoroughly. In this sense, this work presents production of novel and dual nature pure Cd (II) phosphor complex based on ρ‐dimethylaminobenzaldehyde thiosemicarbazone ligand (H‐DMABTS). The structural characterization confirms that the ligand which acts as monoanionic bidentate through NS donor sites, forming mononuclear complex formulates as: [Cd (DMABTS) 2 (C 2 H 5 OH) 2 ] where, DMABTS = anionic form of ρ‐dimethylaminobenzaldehyde thiosemicarbazone. TEM analysis shows that Cd (II) complex has sheet like shape in micro scale. Moreover, the Cd (II) complex was dispersed into silica host. Photoluminescence emission and lifetime of H‐DMABTS ligand, Cd (II) complex and Cd (II) complex dispersied into silica were measured. Cd (II) complex is intensive luminescent with impressive visual emission under UV excitation. All fluorescent materials were tested for their in vitro cytotoxicity against HepG‐2 cell line. The Cd (II) phosphor complex shows higher activity (IC 50 = 0.005 μM) than other prepared materials and different standard antitumor drugs. Furthermore, the Cd (II) phosphor complex has a lower toxicity value (LD 50 = 130 mg/Kg) relative to the standard cis ‐platin (LD 50 = 13.5 mg/Kg). Moreover, latent prints details, including their characteristic three levels, have been clearly identified from various forensic substrates (non‐porous, semi‐porous, porous) using Cd (II) phosphor complex.