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Tin(IV) complexes of 2‐benzoylpyridine N (4)‐phenyl‐thiosemicarbazone: spectral characterization, structural studies and antifungal activity
Author(s) -
Rebolledo Anayive P.,
de Lima Geraldo M.,
Gambi Lillian N.,
Speziali Nivaldo L.,
Maia Daniel F.,
Pinheiro Carlos B.,
Ardisson José D.,
Cortés Maria Esperanza,
Beraldo Heloisa
Publication year - 2003
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.547
Subject(s) - chemistry , semicarbazone , tin , deprotonation , antifungal , ligand (biochemistry) , stereochemistry , crystal structure , candida albicans , medicinal chemistry , crystallography , organic chemistry , ion , receptor , biochemistry , microbiology and biotechnology , biology
Three tin(IV) complexes of 2‐benzoylpyridine N (4)‐phenylthiosemicarbazone (H2Bz4Ph) were prepared: [Sn(L)Cl 3 ] (1), [BuSn(L)Cl 2 ] (2) and [(Bu) 2 Sn(L)Cl] (3), in which L stands for the anionic ligand formed upon complexation with deprotonation and release of HCl. The complexes were characterized by a number of spectroscopic techniques. The crystal structures of H2Bz4Ph and complex 3 were determined. The antifungal activity of the ligand and its tin(IV) complexes was tested against Candida albicans . The thiosemicarbazone proved to be more active than the tin(IV) complexes. Copyright © 2003 John Wiley & Sons, Ltd.