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Synthesis, spectral properties, in vitro α‐glucosidase inhibitory activity and quantum chemical calculations of novel mixed‐ligand M(II) complexes containing 1,10‐phenanthroline
Author(s) -
Avcı Davut,
Altürk Sümeyye,
Sönmez Fatih,
Tamer Ömer,
Başoğlu Adil,
Atalay Yusuf,
Kurt Belma Zengin,
Dege Necmi
Publication year - 2020
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.5412
Subject(s) - chemistry , fourier transform infrared spectroscopy , ligand (biochemistry) , phenanthroline , mass spectrometry , crystallography , infrared spectroscopy , density functional theory , powder diffraction , stereochemistry , analytical chemistry (journal) , nuclear chemistry , computational chemistry , organic chemistry , receptor , biochemistry , physics , chromatography , quantum mechanics
A series of mixed‐ligand M(II) complexes containing 1,10‐phenanthroline (phen) and 3‐methylpyridine‐2‐carboxylic acid (3‐mpaH) or 6‐methylpyridine‐2‐carboxylic acid (6‐mpaH), namely [Co(3‐mpa) 2 (phen)]·3H 2 O ( 1 ), [Hg(6‐mpa) 2 (phen)]·2H 2 O ( 2 ), [Mn(6‐mpa) 2 (phen)]·2H 2 O ( 3 ), [Co(6‐mpa) 2 (phen)]·H 2 O ( 4 ) and [Ni(6‐mpa) 2 (phen)]·H 2 O ( 5 ), were synthesized for the first time. Among them, 1 was obtained as single crystals. The structural characterization for 1 was conducted using X‐ray diffraction and that for 2 – 5 using mass spectrometry. The IC 50 values for α‐glucosidase inhibition of 1 – 5 were obtained as 0.161 to >600 μM. The spectral properties were also investigated using Fourier transform infrared and UV–visible spectra. Furthermore, to investigate the geometrical parameters, spectral and electronic properties and second‐ and third‐order nonlinear optical parameters for 1 – 5 , density functional calculations were applied.