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Salicylaldimine‐bridged dinuclear cyclopalladated complexes: Synthesis, characterization and BSA binding studies
Author(s) -
Gao Yan,
Zhang Saimeng,
Li Xiaoguang,
Jiang Shuyao,
Yang Yajing,
Chang Xiaohong
Publication year - 2020
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.5330
Subject(s) - chemistry , bovine serum albumin , fluorescence , fluorescence spectroscopy , stereochemistry , nuclear magnetic resonance spectroscopy , proton nmr , crystallography , biochemistry , physics , quantum mechanics
Salicylaldimine‐bridged dinuclear cyclopalladated complexes were synthesized by the reactions of cyclopalladated chloro dimers [Pd{(4‐R)C 6 H 3 CH=N‐C 6 H 3 –2,6‐ i ‐Pr 2 }( μ ‐Cl)] 2 (R = H; OMe) with salen‐based bridging ligands. The complexes were characterized by FTIR, NMR spectroscopy, elemental analysis and X‐ray crystallography. The binding interaction of cyclopalladated complexes to bovine serum albumin (BSA) was investigated by UV–vis, fluorescence and synchronous fluorescence spectroscopy. The experimental results showed that these Pd (II) complexes could bind to BSA with high affinity and quench its intrinsic fluorescence by a static or combined process. Also the interaction of Pd complexes with BSA affected the conformation of the tryptophan and tyrosine residues.