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Synthesis, characterization and biological evaluation of N ‐substituted triazinane‐2‐thiones and theoretical–experimental mechanism of condensation reaction
Author(s) -
Sujayev Afsun,
Taslimi Parham,
Kaya Ruya,
Safarov Bahruz,
Aliyeva Lala,
Farzaliyev Vagif,
Gulçin İlhami
Publication year - 2020
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.5329
Subject(s) - chemistry , acetylcholinesterase , thiourea , carbonic anhydrase , aldehyde , reagent , stereochemistry , enzyme , organic chemistry , catalysis
The synthesis of triazinthions and their reactions with some nucleophilic reagents have been investigated during this scientific study. Thus, thiourea with a single component has been synthesized as a result of concomitant reactions of aldehyde and amines trials. The structure of the synthesized compounds was confirmed by 1 H, 13 C NMR spectroscopy methods. The inhibitory effects of novel N‐ substituted triazinane‐2‐thione derivatives on acetylcholinesterase (AChE) activity were performed according to the spectrophotometric method of Ellman et al. These novel N‐ substituted triazinane‐2‐thiones derivatives were effective inhibitors of the α ‐glycosidase, cytosolic carbonic anhydrase I and II isoforms (hCA I and II), and Acetylcholinesterase (AChE) enzymes with K i values in the range of 1.01 ± 0.28 to 2.12 ± 0.37 n m for α ‐glycosidase, 13.44 ± 4.39 to 74.98 ± 6.25 n m for hCA I, 10.41 ± 4.8 to 72.6 ± 17.66 n m for hCA II, 36.82 ± 9.95 to 108.48 ± 1.17 n m for AChE, and 624.62 ± 100.34 to 1124.16 ± 205.14 n m for α ‐glycosidase, respectively.