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Harmless glucose‐modified ruthenium complexes suppressing cell migration of highly invasive cancer cell lines
Author(s) -
Lamač Martin,
Horáček Michal,
Červenková Šťastná Lucie,
Karban Jindřich,
Sommerová Lucia,
Skoupilová Hana,
Hrstka Roman,
Pinkas Jiří
Publication year - 2020
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.5318
Subject(s) - chemistry , ruthenium , cisplatin , cancer cell , cell culture , cancer research , ovarian cancer , combinatorial chemistry , cancer , biochemistry , medicine , catalysis , chemotherapy , biology , genetics
Glucose‐substituted ruthenium complexes [(η 6 ‐benzyl‐glucose)RuCp*] + Cl − , where Cp* = η 5 ‐C 5 Me 5 ; benzyl‐glucose = peracetylated benzyl β‐ d ‐glucopyranoside ( 1 ), benzyl β‐ d ‐glucopyranoside ( 2 ), have been prepared and used as efficient antimigration and anti‐invasive agents against metastatic breast cancer cells (MDA‐MB‐231) and cisplatin‐resistant ovarian cancer cells (SK‐OV‐3). In addition, these complexes were found to be essentially non‐toxic against non‐cancerous human kidney cells (HEK293).