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Copper‐catalyzed synthesis of N ‐aryl acridones from 2‐amino benzophenones and aryl boronic acids via sequential double oxidative C–N coupling
Author(s) -
He Yang,
Xu Liang,
Zhang Jinli,
Wei Yu
Publication year - 2020
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.5316
Subject(s) - chemistry , aryl , amination , reagent , catalysis , boronic acid , combinatorial chemistry , oxidative phosphorylation , oxidative coupling of methane , organic chemistry , chelation , biochemistry , alkyl
Pot‐economic synthesis of N ‐aryl acridones was performed with 2‐aminobenzophenones and aryl boronic acids as starting materials. Cu‐catalyzed chelation‐assisted oxidative C–N cross‐coupling reactions were well merged with the following intra‐molecular oxidative dehydrogenative C–H amination reactions under an air atmosphere. The use of reagent capsules can further resolve the compatibility problem of reagents and simplify the operational process, providing a more straightforward access to the target products.