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Synthesis and cytotoxicity of silylalkylthio‐substituted N ‐heterocycles and their hydroselenites
Author(s) -
Arsenyan Pavel,
Rubina Kira,
Shestakova Irina,
Abele Edgars,
Abele Ramona,
Domracheva Ilona,
Nesterova Alena,
Popelis Juris,
Lukevics Edmunds
Publication year - 2003
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.530
Subject(s) - chemistry , fibrosarcoma , cytotoxicity , in vivo , cytotoxic t cell , stereochemistry , selenium , neuroblastoma , in vitro , melanoma , aqueous solution , aqueous medium , cell culture , combinatorial chemistry , organic chemistry , biochemistry , cancer research , genetics , microbiology and biotechnology , biology
Abstract New hydroselenites of the different silylalkylthio‐substituted N ‐heterocycles have been prepared by the reaction of selenium dioxide with N ‐heterocycles in an aqueous medium. Their structure was confirmed by 1 H, 13 C, and 77 Se NMR data. Most of these silylalkylthio‐substituted N ‐heterocycles and their hydroselenites have an expressed cytotoxic activity on the MG‐22A (mouse hepatoma), HT‐1080 (human fibrosarcoma), B16 (mouse melanoma), and Neuro 2A (mouse neuroblastoma) cell lines. Some of the hydroselenites exhibit free‐radical protection simultaneously with a high cytotoxic effect. The substances studied were also active in vivo against sarcoma S‐180. Copyright © 2003 John Wiley & Sons, Ltd.