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Utilizing 2‐phenylpropanal as coupling partner for C‐S bond formation via sequential thioarylation and decarbonylation process: A novel strategy for the synthesis of aryl alkyl sulfides
Author(s) -
Shaikhi Shahidzadeh Elham,
Nowrouzi Najmeh,
Abbasi Mohammad
Publication year - 2019
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.5211
Subject(s) - chemistry , aryl , alkyl , decarbonylation , morpholine , aldehyde , halide , sulfide , organic chemistry , medicinal chemistry , combinatorial chemistry , catalysis
In this study, first direct access to aryl alkyl sulfides employing 2‐phenylpropanal as coupling partner is reported. Diaryl disulfides react with this aldehyde in the presence of morpholine and produce the corresponding sulfide products in high yields. In another part, disulfides are in situ generated in the reaction mixture from aryl halides/CuI/Cyanodithioformate and coupled with 2‐phenylpropanal to access aryl alkyl sulfides.