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Commercial drug norfloxacin as a novel ligand for the copper‐catalyzed N‐arylation of imidazole with aryl halides
Author(s) -
Wu Fengtian,
Nan Chenlong,
Ma Minyang,
Li Huiqin,
Xie Jianwei
Publication year - 2019
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.5195
Subject(s) - chemistry , imidazole , halide , aryl , norfloxacin , aryl halide , combinatorial chemistry , catalysis , ligand (biochemistry) , copper , coupling reaction , organic chemistry , medicinal chemistry , antibiotics , receptor , biochemistry , alkyl , ciprofloxacin
Norfloxacin was used as an efficient ligand for the CuBr‐catalyzed C‐N coupling reaction of imidazole and aryl halides. The protocol presented good functional group compatibility, permitting many aryl halides to react with imidazole to form the desired products in good to excellent yields.