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Nickel‐Catalyzed Decarboxylative C–Si Bond Formation: A Regioselective Cross‐Coupling Between Trialkyl Silanes and α,β‐Unsaturated Carboxylic Acids
Author(s) -
Allam Bharat Kumar,
Azeez Sadaf,
Kandasamy Jeyakumar
Publication year - 2019
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.5192
Subject(s) - silanes , regioselectivity , chemistry , catalysis , nickel , decarboxylation , organic chemistry , carboxylic acid , medicinal chemistry , silane
This report presents the first example of nickel‐catalyzed mild decarboxylative cross‐coupling reaction for the regioselective formation of C–Si bond. An easily accessible and significantly stable Ni (dmg) 2 owes the role of key promoter. This reaction is highly functional group tolerant and offers α,β‐unsaturated silanes in synthetically useful yields. The reaction gives access to the successful utilization of otherwise difficult trialkyl silanes as coupling partners and operates at a moderate temperature, which is beneficial to deal with highly volatile silanes.