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Bovine serum albumin stabilized iron oxide and gold bimetallic heterodimers: Synthesis, characterization and Stereological study
Author(s) -
Nosrati Hamed,
Davaran Soodabeh,
Kheiri Manjili Hamidreza,
Rezaeejam Hamed,
Danafar Hossein
Publication year - 2019
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.5155
Subject(s) - biocompatibility , nanoparticle , chemistry , bovine serum albumin , bimetallic strip , in vivo , nuclear chemistry , nanotechnology , chemical engineering , materials science , chromatography , organic chemistry , catalysis , microbiology and biotechnology , engineering , biology
In this time researchers make a great efforts to develop new hybrid nanoparticles for medical and pharmaceutical applications. Fe 3 O 4 ‐Au hybrid heterodimers have been prepared with superior properties for various claims. Unfortunately, Fe 3 O 4 ‐Au heterodimers are not stable in the physiological medium. In this study, we employed the albumin macromolecules as a stabilizer of Fe 3 O 4 ‐Au hybrid nanoparticles (noted as Fe 3 O 4 ‐Au‐BSA hybrid nanoparticles). After characterization of synthesized nanoparticles by FTIR, UV–Vis, TEM, DLS, DSC, VSM and XRD techniques, the in vitro and in vivo biocompatibility of these nanoparticles were also evaluated. We encountered with an amazing result which confirmed nanoparticles could be stabilized by linking the BSA on the surface of Fe 3 O 4 ‐Au heterodimers. Also, intravenous injection of Fe 3 O 4 ‐Au‐BSA hybrid nanoparticles up to 400 mg/kg to Balb C mice show that these nanoparticles were non‐toxic. The biocompatibility and stereological study had been performed for more than 30 days after nanoparticles administration, using hystomorphometric analysis. Remarkably, to the best of our knowledge, it was the first time the biocompatibility and biodegradability of Fe 3 O 4 ‐Au were studied and evaluated by stereological technique. Further promotion and biomedical usage of this type of hybrid nanoparticles are underway in our laboratory.