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Comparative Studies of Some Novel Cu 2+ and Fe 3+ Chelates Derived From Tricine (L 1 ) by Single Crystal X‐ray, Spectroscopic and Biological Data: Applications to Investigate Antitumor Activity
Author(s) -
Hassan Eman A.,
Nawar Nagwa,
Mostafa Mohsen M.
Publication year - 2019
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.5096
Subject(s) - chemistry , orthorhombic crystal system , monobasic acid , monoclinic crystal system , crystallography , chelation , crystal structure , octahedron , single crystal , crystal (programming language) , x ray crystallography , octahedral molecular geometry , dibasic acid , inorganic chemistry , diffraction , physics , optics , computer science , programming language
Novel Cu 2+ and Fe 3+ chelates derived from L 1 were synthesized and characterized by single crystal X‐ray diffraction. The results indicate that the Fe (III) crystal, [Fe(L 1 ‐H)Cl 2 ], has an orthorhombic structure of the type pc2b while the dimeric Cu (II) crystal, [Cu(L 1 ‐H)Cl … ClCu(L 1 ‐H)], has a monoclinic with space group Cc. X‐ray diffraction and spectroscopic studies revealed that L 1 acts as monobasic tetradentate with octahedral geometry in Fe (III) crystal while it behaves as dibasic tetradentate with distorted‐octahedral in the Cu (II) crystal. Also, the two chelates were characterized by spectral, magnetic and thermal analyses. DFT parameters were used to prove the liberation of a proton from COOH rather than NH groups. The kinetic and thermodynamic parameters of Fe (III) chelate were determined by Coats‐Redfern and Horowitz‐Metzger methods. Cyclic voltammogram provides information about the oxidation states of Cu (II) and Fe (III) chelates. Antitumor activity against Epitheliod carcinoma (Hela), breast cancer ( MCF‐7 ) and antibacterial activities of chelates were investigated.