Premium
Zirconium catalyzed amide formation without water scavenging
Author(s) -
Lundberg Helena,
Tinnis Fredrik,
Adolfsson Hans
Publication year - 2019
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.5062
Subject(s) - chemistry , scavenging , catalysis , zirconium , amide , homogeneous , metal , organic chemistry , combinatorial chemistry , antioxidant , physics , thermodynamics
A scalable homogeneous metal‐catalyzed protocol for direct amidation of carboxylic acids is presented. The use of 2–10 mol% of the commercially available Zr(Cp) 2 (OTf) 2 ·THF results in high yields of amides at moderate temperature, using an operationally convenient reaction protocol that circumvents the use of water scavenging techniques.