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The use of Cr (CO) 6 as an alternative CO source in Pd‐catalyzed C‐N bond formation: Synthesis of benzamides
Author(s) -
Mozaffari Mozhdeh,
Nowrouzi Najmeh,
Abbasi Mohammad
Publication year - 2019
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.5049
Subject(s) - chemistry , catalysis , aryl , functional group , reaction conditions , combinatorial chemistry , atmospheric pressure , organic chemistry , medicinal chemistry , alkyl , polymer , oceanography , geology
An efficient strategy for the synthesis of benzamides from acetamides and aryl iodides using 1 mol% Pd (OAc) 2 as catalyst and Cr (CO) 6 as CO‐precursor is described. This new synthetic methodology displays high functional group tolerance on both substrates and avoids the need for ligands, reducing agents, or other additives. The corresponding products were obtained in good to excellent yields at atmospheric pressure under mild reaction conditions.