Premium
Physiochemical properties and novel biological applications of Callistemon viminalis ‐mediated α‐Cr 2 O 3 nanoparticles
Author(s) -
Hassan Dilawar,
Khalil Ali Talha,
Solangi Amber Rehana,
ElMallul Ahmed,
Shinwari Zabta Khan,
Maaza Malik
Publication year - 2019
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.5041
Subject(s) - chemistry , nuclear chemistry , dpph , mtt assay , nanoparticle , fourier transform infrared spectroscopy , selected area diffraction , transmission electron microscopy , nanotechnology , antioxidant , organic chemistry , biochemistry , chemical engineering , in vitro , materials science , engineering
We report an eco‐friendly synthesis of α‐Cr 2 O 3 nanoparticles (NPs) using Callistemon viminalis (Bottle Brush) flower extracts as an efficient reducing and capping agent. NPs of sizes 15 nm and 17 nm were synthesized by annealing them at 400°C and 500°C, respectively, which were characterized by X‐ray diffraction, UV–Vis, Fourier transform‐infrared, high‐resolution‐transmission electron microscopy/scanning electron microscopy, SAED, energy‐dispersive X‐ray spectroscopy and SQUID. Microplate‐based assay was used for examining antibacterial potential against 12 pathogenic bacterial strains, and their minimum inhibitory concentrations were calculated. MTT cytotoxic assay was accomplished on Leishmania tropica amastigotes and promastigotes, which revealed IC 50 values of 44 μg/ml and 10.56 μg/ml, respectively. An IC 50 value of 46.32 μg/ml was obtained for HepG2 cancer cells. Enzyme inhibition studies indicated good acetylcholinesterase, moderate butyrylcholinesterase and low alpha‐glucosidase inhibition. Hemolytic assay indicated hemocompatibility at low concentration. In addition, good DPPH radical scavenging and moderate reducing power and total antioxidant potential was revealed by α‐Cr 2 O 3 NPs.