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Tetraphenylporphyrin‐based dual‐functional medical agent for magnetic resonance and fluorescence imaging
Author(s) -
Jin Manyu,
Zhang Yanqun,
Gao Ge,
Xi Qiaoyue,
Tong Jie,
Zhao Yongxia,
Wu Cunqi,
Zhou Hua,
Yang Qiuxia,
Yang Wei,
Xu Jingwei
Publication year - 2019
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.4953
Subject(s) - chemistry , gadolinium , magnetic resonance imaging , mri contrast agent , nuclear magnetic resonance , chelation , imaging agent , tetraphenylporphyrin , ligand (biochemistry) , fluorescence , in vivo , small molecule , porphyrin , photochemistry , inorganic chemistry , organic chemistry , radiology , medicine , biochemistry , physics , microbiology and biotechnology , receptor , quantum mechanics , biology
A bimodal magnetic resonance imaging contrast agent, TPP‐M‐Gd, was developed by modifying tetraphenylporphyrin (TPP) with a small dendritic molecule as a ligand (M) to chelate gadolinium (Gd) ions. The ligand featured four carboxylate groups, which contributed to good water solubility and a strong combination with metal ions. The longitudinal relaxivity ( R 1 ) of the resulting agent was calculated to be 12.45 mM −1 s −1 , which is much higher than that of DTPA‐Gd (4.49 mM −1 s −1 ). The magnetic resonance imaging experiments showed that the newly synthesized contrast agent could enhance T 1 ‐weighted magnetic resonance imaging quality both in vitro and in vivo . In addition, TPP‐M‐Gd exhibited good fluorescent property as shown in cell imaging experiments. The cytotoxicity of TPP‐M‐Gd was even better than that of clinically approved DTPA‐Gd, which makes it a promising dual‐functional medical imaging agent to provide more detailed information about biological and disease‐related events.