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Synthesis, structural studies and antimicrobial evaluation of nickel (II) complexes of NNS tridentate thiosemicarbazone based ligands
Author(s) -
Ibrahim Ahmed B.M.,
Farh Micheal K.,
Mayer Peter
Publication year - 2019
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.4883
Subject(s) - chemistry , semicarbazone , methylene , nickel , crystal structure , crystallography , ligand (biochemistry) , molar conductivity , stereochemistry , inorganic chemistry , medicinal chemistry , elemental analysis , organic chemistry , biochemistry , receptor
Synthesis and characterization of three nickel complexes [NiCl(L 1 )] 1 , [NiCl(L 2 )] 2 and [NiCl(L 3 )] 3 are described {HL 1 = 4‐(2,5‐dimethoxyphenyl)‐1‐((pyridin‐2‐yl)methylene)thiosemicarbazide, HL 2 = 4‐(3‐nitrophenyl)‐1‐((pyridin‐2‐yl)methylene)thiosemicarbazide and HL 3 = 4‐(2,4‐dimethoxyphenyl)‐1‐((pyridin‐2‐yl)methylene)thiosemicarbazide} and among the tridentate ligands HL 3 is reported for the first time. The structures of the complexes were assigned based on CHNS microanalysis, spectroscopic (IR & UV–Vis.) data and solution conductivity studies. The absence of any magnetism for the complexes proved their square planar geometry. Single crystals of complex 1 were grown and analyzed by XRD analysis which confirmed the complex planarity as each Ni atom connects to three (two nitrogen and one sulfur) atoms from the thiosemicarbazone ligand and an additional chlorine atom. Packing of the complex 1 in the crystal lattice was proved to stabilize via intermolecular hydrogen bonds. Antimicrobial activities of 1 – 3 were studied in vitro against fungal and bacterial species and, in several instances, the complexes possessed improved antibacterial behavior in comparison to chloramphenicol.