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Lysosome‐targeted Cyclometalated Iridium (III) Anticancer Complexes Bearing Phosphine‐Sulfonate Ligands
Author(s) -
Du Qing,
Zhao Liping,
Guo Lihua,
Ge Xingxing,
Zhang Shumiao,
Xu Zhishan,
Liu Zhe
Publication year - 2019
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.4746
Subject(s) - chemistry , lysosome , hela , phosphine , fluorescence , iridium , confocal microscopy , stereochemistry , in vitro , microbiology and biotechnology , biochemistry , enzyme , catalysis , quantum mechanics , biology , physics
The synthesis, characterization and biological activity of four cyclometalated Ir (III) complexes ( Ir1 ‐ Ir4 ) containing different phosphine‐sulfonate ligands are reported. Most of these complexes showed good activity against A549 cancer cell lines and the human HeLa cervical cell lines. Spectroscopic properties study displays that all four complexes show rich fluorescence with emission maxima in the range of 474–510 nm. Fluorescence property of these complexes provides a tool to investigate the microscopic mechanism by confocal microscopy. Notably, the typical Ir (III) complex Ir4 can specially localize to lysosome, damage it and induce cell death via apoptosis. In addition, Ir4 enters into A549 cancer cells dominantly through energy‐dependent pathway.