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Synthesis and radioprotective study of new siladithioacetals and germadithioacetals
Author(s) -
Célariès Benoît,
Amourette Christine,
Lion Claude,
Rima Ghassoub
Publication year - 2003
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.472
Subject(s) - chemistry , organosilicon , cysteamine , toxicity , molecule , stereochemistry , organic chemistry , combinatorial chemistry
A series of organosilicon and organogermanium compounds derived from cysteamine, methylcysteamine and 2‐[1‐(1‐naphthyl)ethyl]‐2‐imidazoline have been prepared and their radiopharmacological properties (radioprotective activity and toxicity) have been determined in mice. A number of these new organometallic derivatives have been found to possess radioprotective activity. We have also noted a notable decrease of the toxicity and a fairly large increase in the radioprotective activity in comparison with the unsubstituted organic molecules. Copyright © 2003 John Wiley & Sons, Ltd.