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Polymer complexes. LXXII. Spectroscopic studies, thermodynamics, DNA binding and biological activity of polymer complexes
Author(s) -
ElSonbati A.Z.,
Diab M.A.,
Serag L.S.
Publication year - 2019
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.4670
Subject(s) - chemistry , polymer , ligand (biochemistry) , binding constant , crystallography , stereochemistry , binding site , organic chemistry , biochemistry , receptor
A novel series of copper polymer complexes ( 1 – 4 ) were synthesized and characterized using various spectroscopic techniques. Spectra of all polymer complexes a tetragonal distorted geometry for the Cu(II) ion. The electronic spectra, magnetic moments and electron spin resonance results indicate tetragonal distortion geometry for the Cu(II) polymer complexes. The effects of various solvents on absorption spectra of the ligand are discussed. A prediction of the interaction of the ligand against anti‐cancer receptors was carried out using AutoDock server. The affinity of the compounds to calf thymus DNA was determined through UV–visible DNA binding titration, and intrinsic binding constant ( K b ) was found to be 4.16 × 10 3 , 3.10 × 10 5 , 3.18 × 10 4 and 2.91 × 10 5 for polymer complexes 1 – 4 , respectively. The antimicrobial activity of the polymer complexes against bacterial species ( Bacillus cereus , Staphylococcus aureus , Escherichia coli , Klebsiella pneumonia , Enterococcus faecalis and Pseudomonas aeruginosa ) and fungal species ( Aspergillus niger , Fusarium oxysporum and Candida albicans ) was investigated.