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A unique combination of KI/ZnFe 2 O 4 as a catalyst for oxidative Strecker reaction
Author(s) -
Ghandi Leila,
Kazemi Miraki Maryam,
Karimi Meghdad,
Radfar Iman,
Heydari Akbar
Publication year - 2019
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.4616
Subject(s) - chemistry , strecker amino acid synthesis , catalysis , aqueous solution , oxidative phosphorylation , organic chemistry , reaction conditions , combinatorial chemistry , biochemistry , enantioselective synthesis
α‐Aminonitriles as key intermediates for the preparation of α‐amino acid derivatives, amides, diamines, peptides, proteins and heterocycles were synthesized through methylarene oxidation in the Strecker reaction using a unique combination of KI/ZnFe 2 O 4 as the best catalyst and aqueous tert ‐butyl hydroperoxide as oxidant. A wide range of amines and methylarenes were converted to the corresponding products. Operational simplicity, short reaction time and recyclability of the catalyst are advantages of this protocol.