Isatin‐SO 3 H coated on amino propyl modified magnetic nanoparticles (Fe 3 O 4 @APTES@isatin‐SO 3 H) as a recyclable magnetic nanoparticle for the simple and rapid synthesis of pyrano[2,3‐d] pyrimidines derivatives

Isatin‐SO 3 H coated on amino propyl modified magnetic nanoparticles (Fe 3 O 4 @APTES@isatin‐SO 3 H) is found to be a novel, efficient, and reusable magnetic nanocatalyst, and characterized by FT‐IR, SEM, TEM, XRD, EDX, VSM, and TGA analysis. The magnetic nanocatalyst demonstrated outstanding performance in synthesis of pyrano[2,3‐d] pyrimidines derivatives via one‐pot three‐component reaction of various aromatic aldehydes 1, malononitrile 2, and barbituric acid 3 under reflux conditions in mixture of H 2 O:EtOH (1:1) as solvent. Easy workup procedure, short reaction time, high yield, simple preparation and easy recovery of the catalyst, mild reaction conditions are some advantages of this work.