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Synthesis and Characterization of VO 2+ , Co 2+ , Ni 2+ , Cu 2+ and Zn 2+ Complexes of a Schiff base ligand derived from ethyl 2‐amino‐6‐ethyl‐4,5,6,7‐tetrahydrothieno[2,3‐c]pyridine‐3‐carboxylate and their Investigation as fungicide Agents
Author(s) -
Shakdofa Mohamad M.E.,
Labib Ammar A.,
AbdelHafez Naglaa A.,
Mousa Hanan A.
Publication year - 2018
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.4581
Subject(s) - chemistry , deprotonation , ligand (biochemistry) , protonation , carboxylate , octahedron , crystallography , schiff base , monobasic acid , stereochemistry , pyridine , metal , medicinal chemistry , crystal structure , ion , polymer chemistry , organic chemistry , biochemistry , receptor
Complexes of VO 2+ , Co 2+ , Ni 2+ , Cu 2+ , and Zn 2+ ethyl‐6‐ethyl‐2‐((2‐hydroxybenzylidene)amino)‐4,5,6,7‐tetrahydrothieno[2,3‐c]pyridine‐3‐carboxylate were synthesized and characterized via different spectroscopic techniques. The whole results declared that the complexes assembled in 1:1 mole ratio furthermore, the spectroscopic data analysis proved the present ligand adhered to the different metal ions in neutral or monobasic tridentate ligand via azomethine nitrogen, carbonyl oxygen atoms and protonated/deprotonated phenolic hydroxyl group. The UV–Vis. and ESR spectroscopic data analysis proposed a distorted octahedral or octahedral structure for all complexes. The ESR spectra for Cu 2+ complexes (5–6) revealed an axial symmetry with g‖ > g ┴ > g e , denoting to distorted octahedral Cu 2+ complex and the free electrons in the M shell exist in a d (x2‐y2) orbital with a remarkable covalent bond aspect. The synthesized complexes showed moderate to superb fungicide activity. All complexes are more active than both standard drug and ligand against C. albicans where complexes (5–7) are more active against A. flavus and compounds (1), (4–5), (7) against S. cerevisiae whereas only complex (6) is more active against A niger .