Premium
Synthesis and characterization of superparamagnetic nanohybrid Fe 3 O 4 /NH 2 ‐Ag as an effective carrier for the delivery of acyclovir
Author(s) -
Hoseininasr Atefe S.,
Tayebee Reza
Publication year - 2018
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.4565
Subject(s) - superparamagnetism , thermogravimetric analysis , tetraethyl orthosilicate , nuclear chemistry , fourier transform infrared spectroscopy , nanoparticle , chemistry , magnetite , magnetic nanoparticles , transmission electron microscopy , drug delivery , hydrothermal circulation , chemical engineering , hydrothermal synthesis , drug carrier , nanotechnology , materials science , organic chemistry , magnetization , metallurgy , physics , quantum mechanics , magnetic field , engineering
In this work, superparamagnetic nanohybrid material Fe 3 O 4 /NH 2 ‐Ag is uncovered as an attractive magnetic carrier for the controlled delivery of acyclovir (ACV). This magnetic nanoparticle was synthesized using the hydrothermal method. Then, the surface hydroxyl groups were extended by treating with tetraethyl orthosilicate (TEOS) and (3‐aminopropyl) trimethoxysilane (APTMS). Finally, Ag nanoparticles were created on the surface of Fe 3 O 4 @SiO 2 ‐NH 2 nanospheres via reduction of Ag + ions. Decorated hybrid magnetite nanoparticles were then loaded with ACV as an active antiviral drug model. For this purpose, the amount of loading/release of the drug was investigated at different pH values. Structural characteristics of the functionalized nanomagnetic materials were investigated by Fourier transform‐infrared spectroscopy, transmission electron microscopy, X‐ray diffraction, thermogravimetric analysis and vibrating‐sample magnetometry. The findings indicated that Fe 3 O 4 /NH 2 ‐Ag is highly efficient in loading and release of the selected model drug at pH 7.4.