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Mononuclear Co(III), Ni(II) and Cu(II) complexes of 2‐(2,4‐dichlorobenzamido)‐ N' ‐(3,5‐di‐ tert ‐butyl‐2‐hydroxybenzylidene)benzohydrazide: Structural insight and biological assay
Author(s) -
Chimmalagi Geeta H.,
Kendur Umashri,
Patil Sunil M.,
Frampton Christopher S.,
Gudasi Kalagouda B.,
Barretto Delicia A.,
Mangannavar Chandrashekhar V.,
Muchchandi Iranna S.
Publication year - 2019
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.4557
Subject(s) - chemistry , monoclinic crystal system , tautomer , hydrogen bond , octahedral molecular geometry , ligand (biochemistry) , crystal structure , metal , stereochemistry , octahedron , crystallography , molecule , dpph , medicinal chemistry , antioxidant , organic chemistry , biochemistry , receptor
A series of mononuclear metal complexes of Co(III), Ni(II) and Cu(II) with 2‐(2,4‐dichlorobenzamido)‐ N′ ‐(3,5‐di‐ tert ‐butyl‐2‐hydroxybenzylidene)benzohydrazide ( LH 3 ) have been synthesized and characterized using various physico‐chemical, spectroscopic and single crystal X‐ray diffraction techniques. Structural studies of [Co( LH )( LH 2 )]·H 2 O ( 4 ) revealed the presence of both amido and imidol tautomeric forms of LH 3 , resulting in a distorted octahedral geometry around the Co(III) ion. [Ni( LH )(H 2 O)]·H 2 O ( 5 ) and [Cu( LH )(H 2 O)]·H 2 O ( 6 ) are isomorphous structures and crystallize in the monoclinic P 2 1 / c space group. The crystal structures of 4 , 5 and 6 are stabilized by hydrogen bonds formed by the enclathrated water molecules, C‐H···π and π···π interactions. Complexes along with the ligand ( LH 3 ) were screened for their in vivo anti‐inflammatory activity (carrageenan‐induced rat paw edema method) and in vitro antioxidant activity (DPPH free radical scavenging assay). Metal complexes have shown significant anti‐inflammatory and antioxidant potential.