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Dipeptide‐functionalized MIL‐101(Fe) as efficient material for ibuprofen delivery
Author(s) -
Rajab Asadi Fatemeh,
Hamzavi Seyedeh Fazileh,
Shahverdizadeh Gholam Hossein,
Ilkhchi Mahdi Ghasedi,
HosseinzadehKhanmiri Rahim
Publication year - 2018
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.4552
Subject(s) - thermogravimetric analysis , chemistry , dipeptide , ibuprofen , fourier transform infrared spectroscopy , amine gas treating , elemental analysis , scanning electron microscope , isocyanide , infrared spectroscopy , nuclear chemistry , drug delivery , adsorption , metal organic framework , thermal analysis , polymer chemistry , chemical engineering , organic chemistry , thermal , amino acid , materials science , medicine , biochemistry , composite material , engineering , pharmacology , physics , meteorology
Two derivatives of a dipeptide‐functionalized metal–organic framework were synthesized through isocyanide‐based multi‐component reactions from amine‐containing MIL‐101(Fe). The functionalized materials were characterized by means of Fourier transform infrared spectroscopy, X‐ray diffraction Brunauer–Emmett–Teller measurements, thermogravimetric analysis, elemental analysis and scanning electron microscopy. The performances of these functionalized MIL‐101(Fe) materials with different functions were evaluated for ibuprofen delivery during six days, showing a good ability for adsorption of significant content of the drug and very slow release.