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Cu 1.5 PMo 12 O 40 ‐catalyzed condensation cyclization for the synthesis of substituted pyrazoles
Author(s) -
Yang GuoPing,
He Xing,
Yu Bing,
Hu ChangWen
Publication year - 2018
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.4532
Subject(s) - chemistry , catalysis , yield (engineering) , hydrazide , halogen , condensation , condensation reaction , environmentally friendly , solvent , pyrazole , medicinal chemistry , organic chemistry , physics , ecology , alkyl , materials science , biology , metallurgy , thermodynamics
A convenient and direct approach has been developed for the preparation of pyrazole derivatives by the condensation cyclization of hydrazines/hydrazide and 1,3‐diketones in the presence of Cu 1.5 PMo 12 O 40 (0.33 mol%) under mild conditions (r.t.‐60 °C, 10–30 min). Notably, the reaction was found to be scalable as 99% yield was obtained when the reaction was performed at a 5‐mmol scale. This solvent‐free and halogen‐free catalytic system represents an effective economic and environmentally friendly method for the construction of pyrazoles.