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The enhanced biological activities of three Zn (II) complexes based on different 1,2,4‐triazole fungicides
Author(s) -
Ren Guoyu,
Li Jie,
Wei Xuzhan,
Zhou Jinhua,
Yan Biao,
Guo Zhaoqi,
Ren Yinghui,
Sun Xiaohong,
Ma Haixia
Publication year - 2018
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.4474
Subject(s) - chemistry , hexaconazole , fungicide , triazole , antifungal , paclobutrazol , metal , medicinal chemistry , stereochemistry , nuclear chemistry , crystallography , organic chemistry , botany , biology , medicine , dermatology , carbendazim
In order to screen effective fungicides, three Zn (II) complexes, [Zn L 1 4 (NO 3 ) 2 ]·2H 2 O·2EtOH ( 1 ), [Zn L 2 4 (NO 3 ) 2 ] ( 2 ), and [Zn L 3 4 (DMF) 2 ](NO 3 ) 2 ( 3 ), ( L 1 = paclobutrazol, L 2 = diniconazole, and L 3 = hexaconazole), were synthesized and characterized by elemental analysis, FT‐IR spectroscopy, and single‐crystal XRD. The antifungal activities of these complexes were then evaluated against four selected fungi using the mycelial growth rate method. The resulting data indicate that all the complexes show the enhanced antifungal activities than the corresponding ligand and mixtures. And, the interactions between the metal salt and ligands in the three complexes seem to be synergistic. According to the study of the influence of the structures on the activity, complex 2 with C=C linkage and 2,4‐dichlorophenyl moieties enhances the bioactivity significantly, especially against Wheat gibberellic ( II ). Density functional theory (DFT) calculations were carried out to help explain the enhanced bioactivity of the Zn (II) complexes. Meanwhile, all complexes are excellent grow‐regulators, especially complex 3 . The resulting data show that the complexes based on triazole fungicides have the potential applications in agriculture.