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Synthesis of a novel boronated 1‐aminocyclobutanecarboxylic acid as a potential boron neutron capture therapy agent
Author(s) -
Kabalka George W.,
Yao MinLiang
Publication year - 2003
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.445
Subject(s) - chemistry , boron , neutron capture , amino acid , molecule , strecker amino acid synthesis , combinatorial chemistry , neutron , radiochemistry , organic chemistry , biochemistry , catalysis , nuclear physics , enantioselective synthesis , physics
A boronated aminocyclobutanecarboxylic acid was synthesized for potential use in neutron capture therapy. The synthesis involves the preparation of hydroxymethylcyclobutanone ketal, which is then converted to an amino acid using Bucherer–Strecker methodology. The molecule is modeled after the unnatural amino acid, 1‐aminocyclobutanecarboxylic acid, which has demonstrated high uptake in brain tumors. Copyright © 2003 John Wiley & Sons, Ltd.