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Synthesis, structure and antiproliferative activity of dinuclear ruthenium arene complexes with differently coordinated thiosemicarbazones
Author(s) -
Su Wei,
Li Yuchun,
Xiao Junan,
Zhang Yuexing,
Li Peiyuan
Publication year - 2018
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.4420
Subject(s) - chemistry , ruthenium , stereochemistry , crystallography , density functional theory , cytotoxicity , crystal structure , single crystal , dna , in vitro , computational chemistry , organic chemistry , biochemistry , catalysis
A series of di‐nuclear ruthenium arene complexes with TSC ligands ([( η 6 ‐ p ‐cymene)Ru(N 1 ,S‐TSC)] 2 Cl 2 , A‐type, 1 and 2 ) and their corresponding analogues ([( η 6 ‐ p ‐cymene)Ru(N 2 ,S‐TSC)] 2 Cl 2 , B‐type, 3 and 4 ), in which TSCs act as different coordination mode, have been synthesized and structurally characterized by a variety of physical methods. The molecular structures of 1 , 3 and 4 were determined using single‐crystal X‐ray diffraction analysis. The Gibbs free energy of the two examples of the two types of complexes ( 1 and 3 ) and bonding order in their single‐crystals were discussed using density functional theory (DFT) calculations. The compounds were further evaluated for their in vitro antiproliferative activities against several cancerous and HEK‐293 T noncancerous cell lines, and the results indicate that B‐type complexes show stronger cytotoxicity than A‐type complexes. Furthermore, the interactions of the compounds with DNA were investigated by electrophoretic mobility spectrometry studies.