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Transition metal complexes of a hydrazone–oxime ligand containing the isonicotinoyl moiety: Synthesis, characterization and microbicide activities
Author(s) -
Shakdofa Mohamad M.E.,
ElSaied Fathy A.,
Rasras Anas J.,
AlHakimi Ahmed N.
Publication year - 2018
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.4376
Subject(s) - chemistry , monobasic acid , ligand (biochemistry) , oxime , denticity , crystallography , imine , stereochemistry , moiety , hydrazone , octahedral molecular geometry , deprotonation , octahedron , medicinal chemistry , crystal structure , polymer chemistry , organic chemistry , biochemistry , receptor , catalysis , ion
Complexes of VO 2+ , Mn 2+ , Co 2+ , Ni 2+ , Cu 2+ , Zn 2+ , Ru 3+ and UO 2 2+ with (3‐(hydroxyimino)butan‐2‐ylidene)isonicotinohydrazide were synthesized and characterized using physical and spectral methods. Analytical data revealed that the complexes formed in 1:1 or 1:2 metal–ligand ratios. Spectral studies showed that the ligand bonded to the metal ion in neutral tridentate, monobasic tridentate or monobasic bidentate fashion through azomethine nitrogen atom, protonated/deprotonated imine oxime group and/or ketonic/enolic carbonyl group. From the electronic spectral data together with magnetic susceptibility values a square planar, tetrahedral or distorted octahedral structure can be proposed for all complexes. Electron spin resonance spectra for Cu 2+ complexes ( 2 – 4 ) revealed axial symmetry with g || > g ⊥ > g e , indicating distorted octahedral or square planar structures and the unpaired electron exists in a dx 2 − y 2orbital with marked covalent bond feature. The prepared complexes showed good to excellent biological activity, and the most active complexes against Aspergillus niger were 4 and 9 with zone of inhibition of 25 and 23 mm, respectively. Complexes 10 and 11 showed interesting activity against Escherichia coli with zone of inhibition of 44 and 32 mm, respectively.