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Antibacterial activity of transition metal complexes with a tridentate NNO amoxicillin derived Schiff base. Synthesis and characterization
Author(s) -
Anacona J.R.,
Mago Kysbel,
Camus Juan
Publication year - 2018
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.4374
Subject(s) - chemistry , schiff base , deprotonation , transition metal , octahedral molecular geometry , antibacterial activity , nuclear chemistry , zinc , molar conductivity , metal , magnetic susceptibility , proton nmr , polymer chemistry , stereochemistry , crystallography , organic chemistry , catalysis , bacteria , ion , biology , genetics
From the reaction of amoxicillin ( 1 ) antibiotic with 2,6−diaminopyridine ( 2 ) an amoxicillin−based Schiff base (HL) ( 3 ) was obtained and its transition metal Schiff base complexes were synthesized. Spectroscopic and physicochemical techniques, namely, UV−Vis, FT−IR, 1 H−NMR, EPR, mass spectrometry, molar conductance, magnetic susceptibility, molecular modelling, together with elemental and thermal analyses, were used to characterize the synthesized compounds. Spectral and magnetic data suggested an octahedral geometry for all the complexes and the general formulae [ML(H 2 O) 3 ][PF 6 ] (M(II) = Mn 2+ ( 4 ), Co 2+ ( 5 ), Ni 2+ ( 6 ), Cu 2+ ( 7 ), Zn 2+ ( 8 ), was proposed for them, where L represents deprotonated tridentate NNO amoxycillin−derived Schiff base. All compounds were screened for antibacterial activity by using agar disc diffusion method. The zinc(II) complex exhibited promising bactericidal activity against E. coli and S. aureus .