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Synthesis and characterization of novel chromone Schiff base complexes as p53 activators
Author(s) -
Shakdofa Mohamad M.E.,
Mousa Hanan A.,
Labib Ammar A.,
AbdElAll Amira S.,
ElBeih Ahmed A.,
Abdalla Mohamed M.
Publication year - 2018
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.4345
Subject(s) - chemistry , schiff base , monobasic acid , chromone , octahedral molecular geometry , deprotonation , tetrahedral molecular geometry , ligand (biochemistry) , moiety , stereochemistry , crystallography , metal , octahedron , polymer chemistry , ion , crystal structure , organic chemistry , biochemistry , receptor
A series of chromone Schiff base complexes were prepared and analytically as well as spectroscopically characterized. The ligand was found to act as a monobasic tridentate ligand bonded covalently or coordinatively to the metal ion via deprotonated hydroxyl group, azomethine nitrogen atom and carbonyl oxygen atom of antipyrine moiety. Both electronic spectra and magnetic measurements indicated an octahedral or a distorted octahedral geometry around the metal ions for all metal complexes except the nickel complex, which had a tetrahedral geometry. In addition, the ability of the newly prepared compounds to activate the tumour suppressor p53 in cancer cells was studied, with zinc and copper complexes showing promising activities for p53 ubiquitination compared with diphenylimidazole (reference drug).