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Mononuclear Co(III), Ni(II) and Cu(II) complexes of tridentate di‐ tert ‐butylphenylhydrazone: Synthesis, characterization, X‐ray crystal structures, Hirshfeld surface analysis, molecular docking and in vivo anti‐inflammatory activity
Author(s) -
Chimmalagi Geeta H.,
Kendur Umashri,
Patil Sunil M.,
Gudasi Kalagouda B.,
Frampton Christopher S.,
Budri Mahantesh B.,
Mangannavar Chandrashekhar V.,
Muchchandi Iranna S.
Publication year - 2018
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.4337
Subject(s) - chemistry , octahedral molecular geometry , monoclinic crystal system , crystallography , crystal structure , hydrogen bond , ligand (biochemistry) , molecule , tautomer , stereochemistry , coordination geometry , biochemistry , receptor , organic chemistry
A new hydrazone (LH 2 ) derived from the condensation of 2‐(4‐fluorobenzamido)benzohydrazide with 3,5‐di‐ tert ‐butyl‐2‐hydroxybenzaldehyde was used to synthesize Co(III), Ni(II) and Cu(II) complexes. These were characterized using various physicochemical, thermal, spectroscopic and single‐crystal X‐ray diffraction techniques. All the complexes crystallize in a monoclinic crystal system with P 2 1 / n space group and Z = 4. Structural studies of [Co(L)(LH)]⋅H 2 O indicate the presence of both amido and imidol tautomeric forms of the ligand, resulting in a distorted octahedral geometry around the Co(III) ion. On the other hand, in the [Ni(L)(DMF)] and [Cu(L)(H 2 O)] complexes, the ligand coordinates to the metal through imidol form resulting in distorted square planar geometry, in which the fourth position is occupied by the oxygen of coordinated DMF in [Ni(L)(DMF)] and by a water molecule in [Cu(L)(H 2 O)]. Hirshfeld surface calculations were performed to explore hydrogen bonding and C―H⋅⋅⋅π interactions. Molecular docking studies were carried out to study the interaction between the synthesized compounds and proteins (cyclooxygenase‐2 and 5‐lipoxygenase). The complexes along with the parent ligand were screened for their in vivo anti‐inflammatory activity, using the carrageenan‐induced rat paw oedema method. The complexes show significant anti‐inflammatory potencies.