Premium
Au(III) complexes loaded pH‐responsive magnetic nanogels for cancer therapy
Author(s) -
Rezaei Seyed Jamal Tabatabaei,
Norouzi Khadijeh,
Hesami Ali,
Malekzadeh Asemeh Mashhadi,
Ramazani Ali,
Amani Vahid,
Ahmadi Roya
Publication year - 2018
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.4303
Subject(s) - chemistry , superparamagnetism , hela , nanocarriers , cytotoxicity , in vitro , biophysics , magnetic nanoparticles , nuclear chemistry , nanogel , drug delivery , fluorescence microscope , fluorescence , nanotechnology , nanoparticle , biochemistry , magnetic field , materials science , organic chemistry , magnetization , physics , quantum mechanics , biology
A novel pH‐responsive magnetic nanogels were developed with the aim of targeted delivering and simultaneously releasing of newly synthesized Au(III)‐based anticancer drug, Au(1,7‐Phen)Br 3 . The obtained nanogels were characterized by FT‐IR, DLS, EDAX, TEM, XRD, ICP‐Ms and MRI. The TEM images showed that the nanogels had a spherical shape with a mean diameter of 20 nm. The in vitro release studies of Au (III)‐loaded nanogels showed a pH‐triggered controlled release of drugs. The in vitro cytotoxicity assay of samples to human cervical cancer HeLa cell lines indicated that the Au(III)‐loaded magnetic nanogels exert higher cytotoxicity in comparison with free Au(III) complex. Fluorescent microscope images indicated that these magnetic nanogels possessed notable cell specific targeting in vitro in the presence of an external magnetic field. The results show that this superparamagnetic nanocarrier is a promising candidate for inhibiting growth of tumor cells.