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Novel Pyrimidine‐based Ferrocenyl substituted Organometallic Compounds: Synthesis, Characterization and Biological Evaluation
Author(s) -
Parveen Humaira,
Alsharif Meshari A.,
Alahmdi Mohammed I.,
Mukhtar Sayeed,
Azam Amir
Publication year - 2018
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.4261
Subject(s) - antiprotozoal , chemistry , entamoeba histolytica , pyrimidine , metronidazole , stereochemistry , group 2 organometallic chemistry , combinatorial chemistry , in vitro , organic chemistry , antibiotics , biochemistry , molecule , microbiology and biotechnology , biology
Some novel pyrimidine‐based ferrocenyl substituted organometallic compounds were synthesized via multistep reactions, well characterized by different spectroscopic techniques and elemental analyses and evaluated for in vitro antiprotozoal susceptibility against HM1: IMSS strain of Entamoeba histolytica . The results of antiprotozoal susceptibility unveiled these compounds, as new leads in protozoal chemotherapy as most of the organometallics displayed an exceptionally higher antiamoebic activity (IC 50 = 0.055 μM ‐ 0.815 μM) than the reference drug metronidazole which gave IC 50 (50% inhibitory concentration) value 1.781 μM in our experiments, concluding that newly synthesized organometallic compounds have potential to be employed as effective antiamoebic agents and these organometallics can be very useful for further optimization work on amoebic chemotherapy.