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Copper(I)‐catalyzed multicomponent reactions in sustainable media
Author(s) -
Pawłowski Robert,
Zaorska Ewelina,
Staszko Sebastian,
Szadkowska Anna
Publication year - 2018
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.4256
Subject(s) - chemistry , copper , biginelli reaction , catalysis , coupling reaction , coupling (piping) , reaction conditions , combinatorial chemistry , green chemistry , nitrogen , organic chemistry , reaction mechanism , metallurgy , materials science
Multicomponent reactions including Biginelli reaction and A 3 coupling are useful synthetic methodologies as they can provide valuable intermediates and building blocks for the synthesis of bioactive natural compounds. The heterocyclic products of these transformations represent antibacterial, antitumor or anti‐inflammatory properties. In presented study, copper‐mediated protocols for Biginelli reaction and A 3 coupling in sustainable solvents were reported. At first, charged NHC copper complexes were synthesized in few steps and characterized using spectroscopic methods followed by preliminary activity tests in sustainable media. Later in this study, Biginelli reaction and A 3 coupling were proceeded using prepared copper catalytic systems under mild conditions. Desired nitrogen‐bearing products were obtained with moderate to very high yields. Some attempts to recycle one of the received NHC copper initiators were also investigated.