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Application of a nanostructured sensor based on graphene‐ and ethyl 2‐(4‐ferrocenyl[1,2,3]triazol‐1‐yl)acetate‐modified carbon paste electrode for determination of methyldopa in the presence of phenylephrine and guaifenesin
Author(s) -
Beitollahi Hadi,
Movlaee Kaveh,
Ganjali Mohammad Reza,
Norouzi Parviz,
Hosseinzadeh Rahman
Publication year - 2018
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.4243
Subject(s) - chemistry , electrode , carbon paste electrode , detection limit , graphene , electrochemical gas sensor , electrochemistry , working electrode , reference electrode , cyclic voltammetry , analytical chemistry (journal) , nanotechnology , organic chemistry , chromatography , materials science
We introduce a new method to determine methyldopa without the interference of phenylephrine and guaifenesin. For this purpose, a carbon paste electrode was modified with graphene and ethyl 2‐(4‐ferrocenyl[1,2,3]triazol‐1‐yl)acetate. According to electrochemical studies, oxidation current of methyldopa on the surface of the modified electrode increased and shifted towards negative potentials. This modified electrode demonstrated two linear ranges of 0.4–30.0 μM and 30.0–500.0 μM with a detection limit of 0.08 μM. No change was observed in the sensitivity of the modified electrode towards methyldopa in the presence of phenylephrine and guaifenesin, which enables the simultaneous or independent measurement of the three moieties. The efficiency of the proposed modified electrode was evaluated through the determination of these substances in real samples.