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Evaluation of UiO‐66 metal organic framework as an effective sorbent for Curcumin's overdose
Author(s) -
Molavi Hossein,
Zamani Mostafa,
Aghajanzadeh Mozhgan,
Kheiri Manjili Hamidreza,
Danafar Hossein,
Shojaei Akbar
Publication year - 2018
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.4221
Subject(s) - chemistry , thermogravimetric analysis , sorbent , adsorption , metal organic framework , fourier transform infrared spectroscopy , nuclear chemistry , desorption , langmuir adsorption model , bet theory , point of zero charge , analytical chemistry (journal) , inorganic chemistry , chemical engineering , organic chemistry , engineering
Metal organic frameworks (MOFs) UiO‐66 (UiO stands for University of Oslo) and NH 2 ‐UiO‐66 were prepared and characterized as sorbent (antidotal agents) for curcumin (CUR) adsorption. The structure of products were characterized by X‐ray powder diffraction (XRD), Field emission scanning electron microscopy (FESEM), thermogravimetric analysis (TGA), Attenuated Total Reflectance‐Fourier transform infrared spectroscopy (ATR‐FTIR), and N 2 adsorption–desorption measurements. FESEM showed NH 2 ‐UiO‐66 displayed symmetrical crystals with triangular base pyramid morphology, with the particle size around 100 nm and uniform size distribution. Adsorption capacities of CUR/MOFs with different mass ratios in the feed were investigated in the present study, and this investigation revealed that when the CUR/MOFs with mass ratio was around 0.4, the absorption capacity of NH 2 ‐UiO‐66 had tended to maximum. Although, functionalization reduced the specific surface area and free volume, introducing polar amine groups could improve the affinity of NH 2 ‐UiO‐66 respect to CUR. Kinetic studies showed that the kinetic data are well fitted with the pseudo‐ second‐order model. MTT assay revealed that MOFs at the concentration range of 0–560 μg/ml had no cytotoxic effect on the Human Foreskin Fibroblast normal cell line (HFF‐2). These results suggest that these MOFs could be safe as sorbent for adsorb CUR from the body.