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Anti‐neurotoxic evaluation of synthetic and characterized metal complexes of thiosemicarbazone derivatives
Author(s) -
ElSaied Fathy A.,
Salem Tarek A.,
Shakdofa Mohamad M.E.,
AlHakimi Ahmed N.
Publication year - 2018
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.4215
Subject(s) - chemistry , semicarbazone , quinoline , metal , chelation , sulfur , thiol , medicinal chemistry , penicillamine , stereochemistry , inorganic chemistry , organic chemistry
Quinoline‐2‐caboxyaldehyde thiosemicarbazone (HL 1 ) and quinoline ‐2‐caboxyaldehyde N‐dimethyl thiosemicarbazone (HL 2 ) metal complexes were prepared and characterized using analytical and spectroscopic techniques. The measurements showed that ligands behave as monovalent or neutral tridentate ligands bonding via azomethine, quinoline ring nitrogen atoms and sulfur atoms in thiol or thion forms. The anti‐neurotoxic effect of ligands and their complexes showed that, exposure to aluminum increase oxidative stress in the brain, an effect that could be offset by concomitant thiosemicarbazone complexes. Complexes could be having an effect on absorption or excretion of aluminum, due to their chelating activity. These findings may shed light on the potential clinical importance of thiosemicarbazone complexes in Alzheimer's disease.