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RAPTA complexes containing N‐substituted Tetrazole scaffolds: Synthesis, characterization and Antiproliferative activity
Author(s) -
Mandal Poulami,
Malviya Novina,
Kundu Bidyut Kumar,
Dhankhar Sandeep Singh,
Nagaraja C.M.,
Mukhopadhyay Suman
Publication year - 2018
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.4179
Subject(s) - chemistry , tetrazole , jurkat cells , ruthenium , ligand (biochemistry) , stereochemistry , decane , combinatorial chemistry , benzene , biological activity , organic chemistry , in vitro , receptor , biochemistry , t cell , immune system , immunology , biology , catalysis
This work describes the synthesis of a series of Ru(II)‐Arene (Arene= p ‐cymene, benzene) complexes using different N ‐substituted tetrazole ligands and their PTA analogues. All the complexes have been characterized thoroughly using different analytical techniques. Antiproliferative activity of the synthesized complexes against different cell lines indicates remarkable activity of certain complexes up to nanomolar level. In few cases introduction of water soluble PTA (PTA = 1,3,5‐ triaza‐7‐phospha‐tricyclo‐[3.3.1.1]decane) ligand induce significant cytotoxic activity in the ruthenium complex with respect to their chloro analogues, particularly against Jurkat and MCF‐7 cell lines. Interaction with different biomolecules and stability of the RAPTA complexes have been explored in pseudo‐pharmacological conditions.