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Pd‐NHC catalysed Carbonylative Suzuki coupling reaction and its application towards the synthesis of biologically active 3‐aroylquinolin‐4 (1 H )‐one and acridone scaffolds
Author(s) -
Ghosh Prasanjit,
Ganguly Bhaskar,
Das Sajal
Publication year - 2018
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.4173
Subject(s) - chemistry , acridone , yield (engineering) , combinatorial chemistry , suzuki reaction , substrate (aquarium) , catalysis , coupling reaction , biological activity , organic chemistry , palladium , in vitro , biochemistry , materials science , oceanography , metallurgy , geology
We have unfolded a convenient and mild protocol for the synthesis of diaryl ketones via Pd‐ NHC catalysed carbonylative Suzuki coupling reaction. Notably, this method offers advantages like no use of toxic CO gas, shorter reaction time, high yield, and broad substrate scope. Several sensitive functional groups (like‐COMe, ‐COOMe, ‐F, ‐Cl, ‐Br, ‐NH 2 , ‐CN) are well tolerated in this reaction. In addition, we have also demonstrated a new efficient route for the synthesis of biologically active and pharmaceutically important 2‐substituted 3‐Aroylquinolin‐4(1 H )‐ones and acridone scaffolds.