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Pd/C: An efficient and reusable catalyst for the synthesis of flavones via carbonylation of aryl halides
Author(s) -
Lei Yizhu,
Li Zhi,
Wan Yali,
Zhou XiaoYu,
Li Guangxing,
Shi Kaiyi
Publication year - 2018
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.4163
Subject(s) - chemistry , flavones , carbonylation , catalysis , aryl , phosphine , halide , combinatorial chemistry , organic chemistry , catalytic cycle , aryl halide , medicinal chemistry , palladium , carbon monoxide , alkyl , chromatography
This work describes an efficient and mild approach for the synthesis of flavones via catalytic carbonylation of aryl halides with 2‐hydroxyacetophenone using the commercial Pd/C as an efficient, heterogeneous and recyclable catalyst. Under balloon pressure of CO, 0.6 mol% Pd/C is sufficient for moderate yields of flavones for the carbonylation of aryl iodides under phosphine‐free conditions and aryl bromides in the presence of phosphine ligand. The catalyst is easily separable and shows significant recyclability. Moreover, the reaction mechanism was discussed, and a possible mechanism that contains two different cyclisation pathways was proposed.