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MNPs@SiO 2 ‐Pr‐AP: A new catalyst for the synthesis of 2‐amino‐4‐aryl thiazole derivatives
Author(s) -
GhorbaniVaghei Ramin,
Alavinia Sedigheh,
Merati Zohreh,
Izadkhah Vida
Publication year - 2018
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.4127
Subject(s) - chemistry , thiourea , catalysis , thiazole , aryl , pyridine , ethylbenzene , combinatorial chemistry , organic chemistry , medicinal chemistry , alkyl
A simple and efficient synthesis of 2‐amino‐4‐aryl thiazole derivatives was carried out through the reaction of substituted acetophenones and thiourea using three different types of catalytic systems including N,N,N′,N′‐tetrabromobenzene‐1,3‐disulfonamide [TBBDA], poly(N,N′‐dibromo‐N‐ethylbenzene‐1,3‐disulfonamide) [PBBS] and a combination of TBBDA and nano‐magnetic catalyst supported with functionalized 4‐amino‐pyridine silica (MNPs@SiO 2 ‐Pr‐AP). The results showed that the use of TBBDA along with the MNPs@SiO 2 ‐Pr‐AP gains the highest yields of the products in the shortest reaction time.