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Nanomagnetically modified vitamin B 3 (Fe 3 O 4 @Niacin): An efficient and reusable green biocatalyst for microwave‐assisted rapid synthesis of 2‐amino‐3‐cyanopyridines in aqueous medium
Author(s) -
Afradi Mojgan,
Pour Sjjad Abbasi,
Dolat Maryam,
YazdaniElahAbadi Afshin
Publication year - 2018
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.4103
Subject(s) - malononitrile , chemistry , catalysis , ammonium acetate , green chemistry , decantation , biocatalysis , nuclear chemistry , magnetic nanoparticles , ammonium bromide , superparamagnetism , nanoparticle , organic chemistry , ionic liquid , chemical engineering , high performance liquid chromatography , pulmonary surfactant , biochemistry , engineering , magnetization , physics , quantum mechanics , magnetic field
Superparamagnetic nanoparticles of modified vitamin B 3 (Fe 3 O 4 @Niacin) represent a new, efficient and green biocatalyst for the one‐pot synthesis of 2‐amino‐3‐cyanopyridine derivatives via four‐component condensation reaction between aldehydes, ketones, malononitrile, and ammonium acetate under microwave irradiation in water. This new magnetic organocatalyst was easily isolated from the reaction mixture by magnetic decantation using an external magnet and reused at least six times without significant degradation in the activity. The catalyst was fully characterized by FT‐IR, XRD, SEM, VSM, UV–Vis, DLS and EDS. Excellent yield, very short reaction time (7–10 min), operational simplicity, easy work‐up procedure, avoidance of hazardous or toxic catalysts and organic solvents are the main advantages of this green methodology which makes it more economic than the other conventional methods.