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New organotin supramolecular complexes based on copper cyanide and auxiliary N‐donor ligands as potent inhibitors of cancer cell lines: In vitro and antioxidant experiments
Author(s) -
Etaiw Safaa Eldin H.,
Abdou Safaa N.
Publication year - 2018
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.4053
Subject(s) - chemistry , abts , supramolecular chemistry , in vitro , hela , copper , antioxidant , stereochemistry , biochemistry , crystallography , organic chemistry , dpph , crystal structure
The new synthesized supramolecular complexes (SC); [Cu 2 (CN) 4 (Et 3 Sn) 2 (tbpe)], 1 and [Cu 2 (CN) 3 (Et 3 Sn)(bpe)], 2 (tbpe = trans‐1,2‐bis(4‐pyridyl)ethene and bpe = 1,2‐bis(4‐pyridyl)ethane), were characterized by elemental analyses, electrical conductance, spectroscopic studies and thermal analyses. UV–Vis spectra and magnetic moment data suggested the tetrahedral geometry around Cu(I) atoms. The structures of the SC 1 and 2 were also theoretically studied using molecular mechanics (MM+). The structures were minimized with a semi‐empirical (PM3) method. The organotin compounds represent significant advances in the clinical management of some cancer cell lines. 1 and 2 were tested as inhibitors and their citotoxicities showed potent growth inhibitory activity for hepatocellular carcinoma HePG‐2, mammary gland breast cancer MCF‐7, human prostate cancer PC3 and Colorectal carcinoma HCT‐116 cell lines. The tested compounds showed high inhibitory anti‐oxidant activity either using erythrocyte hemolysis or ABTS method.