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An efficient catalytic method for the synthesis of pyrido[2,3‐ d ]pyrimidines as biologically drug candidates by using novel magnetic nanoparticles as a reusable catalyst
Author(s) -
Moradi Saeid,
Zolfigol Mohammad Ali,
Zarei Mahmoud,
Alonso Diego A.,
Khoshnood Abbas,
Tajally Aria
Publication year - 2018
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.4043
Subject(s) - catalysis , chemistry , sulfonic acid , high resolution transmission electron microscopy , reusability , yield (engineering) , physisorption , magnetic nanoparticles , x ray photoelectron spectroscopy , nanoparticle , nuclear chemistry , chemical engineering , combinatorial chemistry , organic chemistry , materials science , software , transmission electron microscopy , computer science , engineering , metallurgy , programming language
A convenient method for the synthesis of pyrido[2,3‐ d ]pyrimidines by using the novel nano‐magnetic silica‐bonded S ‐sulfonic acid[Fe 3 O 4 @SiO 2 @(CH 2 ) 3 S–SO 3 H] as an efficient and recyclable catalyst under neat conditions is described. The major advantages of the present methodology are high yield, short reaction time, and reusability of the catalyst. Furthermore, the nano‐magnetic silica‐bonded S ‐sulfonic acid was fully characterized by using various techniques such as FT‐IR, TG/DTG, DTA, EDX, μXRF, XRD, HRTEM, SEM, SEM elemental mapping, XPS, and N 2 physisorption. The results obtained from this research support the idea of rational design, synthesis, and applications of task‐specific and reusable catalysts for the preparation of various polynitrogenated heterocyclic compounds containing 1,4‐dihydropyridine moieties.