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In vitro antitumour activity of some organogermanium radioprotectors
Author(s) -
Célariès Benoît,
Gielen Marcel,
de Vos Dick,
Rima Ghassoub
Publication year - 2003
Publication title -
applied organometallic chemistry
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.53
H-Index - 71
eISSN - 1099-0739
pISSN - 0268-2605
DOI - 10.1002/aoc.403
Subject(s) - chemistry , etoposide , in vitro , elemental analysis , nuclear magnetic resonance spectroscopy , germanium , stereochemistry , medicinal chemistry , combinatorial chemistry , organic chemistry , biochemistry , silicon , chemotherapy , medicine , surgery
Abstract Four germanium derivatives of 2,2′‐oxydiethanethiol and 2,2′‐thiodiethanethiol have been synthesized and characterized by 1 H and 13 C NMR, mass spectroscopy and elemental analysis. The antitumour activity of one of them is comparable to those of cis ‐platin and etoposide. Copyright © 2003 John Wiley & Sons, Ltd.